Mesoporous solids were used for hydrogen sulfide removal from stream H2S-Air. These solids were synthesized from a natural montmorillonite clay (STx-1) using the template method with a non-ionic surfactant and exchanged with Fe3+, Cu2+ and Fe3+-Cu2+; additionally, MgO/surfactant-clay solids impregnated with different contents of Zn, Fe-Zn and Cu-Zn were also prepared. The solids were characterized by using XRF, XRD, surface area, TPR and TGA-DTG. An increase in the surface area, pore volume and mesoporosity of STx-1 modified with surfactant was observed. The natural clay modified with surfactant and exchanged with copper cation enhanced the H2S breakthrough capacity. The STx-1 clay impregnated with zinc improved H2S removal, which increased with increasing the zinc content.